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快速切向流深層過濾器 TFDF® for volumes of 1-2000L

快速切向流深層過濾器 TFDF® for volumes of 1-2000L

產品介紹：

​Novel High Flux Single-use Filtration for Fed Batch Clarification that enables 1000 LMH. TFDF ® = tangential flow (TF) + depth filtration (DF) TFDF® 是一款專門針對高細胞密度產物及高細胞裂解細碎雜質澄清/粗濾/過濾而設計的快速切向流深層過濾器~ 一次性使用,提供從研發1 L 到量產規模化 2000 L的工作量範圍

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規格訊息：

​Novel High Flux Single-use Filtration for Fed Batch Clarification  that enables 1000 LMH.
TFDF ® = tangential flow (TF) + depth filtration (DF)

 

      

        

        

Tangential Flow

High cell density

Poor product passage

Depth Filtration

Low cell density

Excellent product passage

Tangential Flow Depth Filtration

High cell density

Excellent product passage

 

 

 

yes切向流的渠道設計

  • Low concentration polarization minimizes fouling and turbidity breakthrough
  • Robustness for challenging feed stocks

​​

​ yes厚壁深層過濾設計

  • High filtration capacity
  • Short, highly inter-connected paths do not retain product

 

yes極大的效益

  • High flux > 1000 LMH
  • Low hold-up volume
  • Small footprint 
  • Simple setup and disposal
  • Scalable from 1-2000L
  • Process < 2  hours

​

        

 

 

 

 

Robust TFDF(3cm2) filter to Clairfication at 650 LMH, 1300 LMH, 1950 LMH

1L CHO HARVEST

at 650 LMH Cell Culture Feed

Volume:1.0 L

%PCV:6.6 %

VCC:2.5 x 107

Viability: 80%

Titer: 3.0 g/L

Turbidity: 1196 NTU

Permeate Pool

Pool Volume: 1.2 L

Process Time: 6 hours

Yield: >90% 

Turbidity: 88 NTU

NTU reduction:92%

 

取代粗澄清過濾

使傳統Depthfilter downsize

at 1300 LMH  Cell Culture Feed

Volume:1.0 L

%PCV:6.6 %

VCC:2.5 x 107

Viability:80%

Turbidity:1182 NTU

Permeate Pool

Pool Volume: 1.2 L

Process Time: 3 hours

Yield:> 90%

Turbidity: 94 NTU

NTU reduction:91%

at 1950 LMH Cell Culture Feed

Volume:1.0 L

%PCV:6.6 %

VCC:2.5 x 107

Viability:80%

Titer:3.0 g/L

Turbidity:1182 NTU

Permeate Pool

Pool Volume:1.2 L

Process Time :1.5 hours

Yield:> 90%

Titer:3.0 g/L

Turbidity:101 NTU

NTU reduction:91%

 

Robust TFDF(1500cm2) filter to Clairfication at 1300 LMH with beneficial impurity levels

500L HARVEST

Cell Culture Feed              

Volume:500L

%PCV:7% 

VCC:1.5 x 107 

Viability: 80%

Titer:3.0 g/L

Comparable or lower HCP and DNA levels to centrifugation and depth filtration

取代粗澄清過濾

使傳統Depthfilter downsize

 

Low Delta P with high throughput

             

No filter fouling with high LMH

Volume :1L

%PCV :6.8% 

VCC : 2.3 x 107 

Viability :92%

Titer :5.9 g/L

CC Feed Turbidity :954 NTU

Permeate Pool Turbidity :92 NTU

Flux :1300 LMH

 

Diafiltration optimization prevents turbidity breakthrough

 

     (TFDF型錄) 

      

ProConnex® TFDF™ Flow Path 

Lab-scale

Pilot-scale

Process-scale

Type 

Filter

Flow path

Flow path

Flow path

Flow path

pore rating 

2–5 µm
TFDF filter Materials  Polypropylene, Polyethylene Terephthalate

Surface area (cm2) 

3

3

150

1500

6000

Recommended process volume 

(L) 

< 1 L

< 1 L

< 50 L

< 500 L

< 2000 L

Total filter length (cm) 

20

20

108

108

108

Effective length (cm) 

2.2

2.2

108

108

108

Number of tubes 

1

1

1

10

40

Standard configuration made to 

stock 

Yes

Yes

No

No

No

Customizable 

N/A

 

Yes

Yes

Yes

Yes

Part number 

TFDF-3

STFDFCL15111N

-

-

-

ProConnex Flow Paths 

       

Actual products subject to change. All images shown for reference only

 

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